Our new assays have arrived

Using the HTRF^® technology

8 assays to detect FGFR1, 2, 3 and 4, both total and phosphorylated:

• FGFR1 phospho Y653/654
• FGFR1 total
• FGFR2 phospho Y653/654
• FGFR2 total
• FGFR3 phospho Y647/648
• FGFR3 total
• FGFR4 phospho Y642
• FGFR4 total

3 assays to detect Rb. Rb acts as a tumor suppressor and regulates cell cycle progression:

• Rb phospho S780
• Rb phospho S807/811
• Rb total

2 kits to detect both total and phosphorylated SMAD2 protein. Smad2 is a receptor-regulated that mediates the signal of the transforming growth factor (TGF)-beta, and regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation:

• SMAD2 phospho S465/467
• SMAD2 total

1 HTRF kit to detect phospho S65 ubiquitin:

• Ubiquitin phospho S65

Cytokine receptor binding

4 assays to detect interaction between IL12, IL23, IL6 and its receptors. IL12 is strongly linked to autoimmunity. IL23 are linked to Crohn’s Disease and psoriasis. And IL6 is involved in various biological processes, including autoimmune diseases and cancers:

• IL12/IL12Rβ1
• IL23/IL12Rβ1
• IL23/IL23R
• IL6/IL6R

Immune checkpoint inhibitors

1 kit to detect LAG3/MHCII interaction. LAG3/MHCII is a checkpoint inhibitor which generates considerable interest in cancer immunotherapy:

• LAG3/MHCII

SARS-CoV-2 N is major immunogen predominantly expressed at early stages of viral infection. The SARS-CoV-2 Spike S1 protein is one of two part of the virus Spike protein (S). The S1 subunit is responsible for the the virus interaction with host cells’ transmembrane Angiotensin-converting enzyme 2 receptors (ACE2):

• SARS-Cov2 capsid kit
• SARS-Cov2 Spike S1
• S1/ACE2

Using the AlphaLISA^® SureFire^® Ultra™ technology

• Total IKKα
• Total IRAK4
• Phospho HDAC4 (S246)
• Total HDAC 4
• Phospho SLP76 (Y113)
• Phospho SLP76 (Y145)
• Phospho-PI3 Kinase p85 (Tyr458) (Mouse)
• Total PI3 Kinase p85
• Phospho-PLC G2 (Y753)
• Phospho-PLC G2 (Y759)
• Phospho-PLC G2 (Y1197)
• Phospho-PLC G2 (Y1217)
• Total PLC G2
• Phospho RIPK1 (S166)
• Total RIPK1
• Phospho RPS6 (S235/236)
• Total RPS6
• Total DAP12
• Phospho MLKL (S358)
• Total MLKL
• Phospho Histone H2A.X (S139)
• Total H2A.X
• Phospho-PLC G1 (Y783)

Using the AlphaLISA^® SureFire^® Ultra™ Multiplex technology

• Phospho (S235/236)/Total S6 RP Multiplex
• Phospho (S240/S244)/Total S6 RP Multiplex
• Total Rb Multiplex
• Phospho Rb (S780)
• Phospho Rb (S807/811
• Phospho Rb (T821/826)
• p-STAT1 (Tyr701) (Eu)
• p-STAT1 (Ser727) (Eu)

Using the Alpha SureFire^® CETSA^® technology

• STING